- Andes Wealth Technologies Named Finalists for Two 2021 Industry Awards
- Candleschtick Launches Online Jewish Gift Store With a Twist of Yiddish Humor
- As American Economy Recovers, Employers Prioritize Education Benefits to Attract and Develop Workers
ASGCT is one of the world's most influential academic conferences in the area of gene and cell therapy. More than 3,500 scholars, clinical investigators, physicians and other professionals attend the meeting every year. The ASCCT annual meeting is held as a virtual event from May 11 to 14 this year.
Dr. Sean Fu, President of Luye Life Sciences Boston R&D Center, and CEO of GeneLeap Biotech, said, "This is the first time that we have presented information on the progress of our scientific research in gene and cell therapy at the ASGCT annual meeting. This reflects the strength of our R&D team's innovation and drug development in this field. We look forward to working with global scientists to expand our scientific progress for translational science and provide greater momentum of innovation for the development of the company in the future."
Details of the latest scientific progress presented by Luye Life Sciences are as follows:
- Immune Suppression with Rapamycin May Cause Prolonged IgM Formation Against AAV Vector
In collaboration with the Indiana University School of medicine, Luye Life Sciences Boston R&D Center and GeneLeap Biotech leveraged the strength of proprietary nanoparticle formulation technology to encapsulate immune suppressive drug rapamycin and compared it with its free form. Studies showed that rapamycin might be a more effective strategy to achieve second dose of AAV gene therapy but induced prolonged IgM responses.
- Strategies in AAV Upstream and Downstream Purification for High Yield Separation of Empty/Full Capsids
Luye Life Sciences Boston R&D Center conducted a series of studies on both the AAV upstream and downstream processes that offers greater feasibility to yield high viral genome and achieve excellent high purity with full AAV capsid. Such successful process will enable the AAV production to meet the demand for supporting both clinical and commercial efforts.
- Optimization of Human FIX Expression Cassettes for Superior Liver-targeted Gene Therapy of Hemophilia B
Together with Luye Life Sciences Boston R&D Center and the Indiana University School of medicine, GeneLeap Biotech identified a candidate drug AAV8.pXLLY027 with superior hFIX expression and improved potency, which holds the great potential to significantly reduce the administration dosage, safety concern and cost burden in clinical application.
- Therapeutic Efficacy of An Investigational AAV Gene Therapy in Alleviating Choroidal Vascularization in Rat Laser-induced CNV Model
GeneLeap Biotech generated an AAV gene therapy clinical lead AAV8.pTHVE002 expressing aflibercept was successfully selected with superior expression and efficacy, which lays a solid foundation for the researchers to advance clinical development of this investigational gene therapy for treating millions of wet AMD patients over the world with one-time administration.
More on Boston Chron
- Inherited An Heirloom Shawl You Cannot Use? Sell It On The Heirloom Bazaar - A Marketplace By Wovensouls
- Got Clutter? Reinvigorate Your Organizing Efforts with The First-In-The-Category Time-Based Organizing Deck of Cards
- Dive Technologies Builds Commercial AUV for Kraken Robotics Fleet
- Boston: Staying on brand in the 2020 Election
- Santé Media Group announces the appointment of James Shannon as Director, National Accounts
Dr. Jason Zhang, CSO of GeneLeap Biotech, said, "We are glad to have this opportunity to share our research in gene and cell therapy, including our clinical leads in hemophilia B and wet-AMD AAV gene therapy, as well as progress in AAV process development and immune tolerance. We look forward to continued collaborations with scholars worldwide in our efforts to address the unmet needs of patients."
About Luye Life Sciences Boston R&D Center
The R&D center at Boston, Woburn, MA is a subsidiary of Luye Life Sciences, developing novel drugs for cancer and genetic disorders, including gene therapy, immune checkpoint inhibitory antibodies, CAR-T cells therapy, and novel drug delivery mechanisms. At present, the AAV platform for gene therapy program developed by the Boston R&D center has several candidates in the pipeline.
About GeneLeap Biotech
GeneLeap Bio., a subsidiary of Luye Life Sciences, specializes in developing gene therapy drugs for cancer and severe infectious diseases, including mRNA and oligonucleotides. Currently, GeneLeap Biotech has R&D operations in both the USA (Boston) and China (Nanjing, Yantai).
SOURCE Luye Life Sciences
Filed Under: Business
Latest on Boston Chron
- Boston: BCYF Camp Joy Program Registering for Summer Now
- Boston Police Department Police Reform Policy update
- Enanta Pharmaceuticals to Participate in Two Investor Conferences in June
- Harvard's Wyss Institute initiates industry partnership to facilitate brain-targeted drug delivery
- VBI Vaccines Announces Results of Annual General Meeting
- nanoMesh™ LLC (a subsidiary of Exogenesis Corporation) Announces Secondary Endpoint Achieved in nanoMesh™ Pathogen Inhibiting Protein (PIP) Uptake Studies
- Boston: Mayor Janey announces the successful expansion of conservation land and affordable housing opportunities in Roslindale
- Revenue Solutions, Inc. Launches Property Premier To Streamline Workflows for Local Government
- NATP offers education on two major post-tax season issues
- Ski Johnson To Begin Jazz For Life Tour June 15th St. John, USVi
- Proctor360 Becomes Awarded Vendor for TIPS Purchasing Cooperative
- Boston: June 2021: Latest updates from the Department of Neighborhood Development
- Boston: Apply today to serve on Community Advisory Board for green jobs
- CORRECTING and REPLACING Vertex Announces U.S. FDA Approval for TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor) in Children With Cystic Fibrosis Ages 6 through 11 With Certain Mutations
- New Hampshire Department of Health and Human Services Brings Pooled Testing to K-12 Classrooms in Partnership with Concentric by Ginkgo
- SQZ Biotechnologies Tolerizing Antigen Carrier (TAC) Program Induces Antigen-Specific Immune Tolerance in Preclinical Models Demonstrating Potential for Broad Applicability Across Autoimmune Diseases
- Starburst Announces Stargate, A Gateway For Global Cross-Cloud Analytics USA - English USA - English
- Ondas Holdings Inc. Prices $44.8 Million Public Offering of Common Stock
- Aspen Aerogels to Discuss Energy Infrastructure Market in Water Tower Research Fireside Chat Series
- Markforged Welcomes Carol Meyers to Board of Directors